Stroke Horizon Scanning Bulletin Volume 13 Issue 6

Stroke December 2021

Contents

WSO Position statement on Stroke care during COVID-19 pandemic | World Stroke Organization (world-stroke.org)

Primary stroke prevention worldwide: translating evidence into action.

Linking the Paul Coverdell National Acute Stroke Program to commercial claims to establish a framework for real-world longitudinal stroke research.

Cilostazol Versus Aspirin on White Matter Changes in Cerebral Small Vessel Disease: A Randomized Controlled Trial

Higher Risk of Ischemic Stroke After an Intracerebral Hemorrhage Than in General Population: A Cohort Study From the United Kingdom.

Outcome Prediction Models for Endovascular Treatment of Ischemic Stroke: Systematic Review and External Validation.

Collateral Supply in Preclinical Cerebral Stroke Models.

Sex differences in predictors for cognitive decline and dementia in people with stroke or transient ischemic attack in the PROGRESS trial .

Estimating nocturnal stroke onset times by magnetic resonance imaging in the WAKE-UP trial.

Comparison of the Safety, Efficacy, and Procedural Characteristics Associated with Proximal and Distal Radial Access for Diagnostic Cerebral Angiography.

Optimal Management of Asymptomatic Carotid Stenosis in 2021: The Jury is Still Out. An International, Multispecialty, Expert Review and Position Statement.

Robust Thrombolytic and Anti-Inflammatory Action of a Constitutively Active ADAMTS13 Variant in Murine Stroke Models.

Considerations for the Implementation of a Telestroke Network: A Systematic Review.

Major research network to investigate body clock and stroke — Nuffield Department of Clinical Neurosciences.

Female Gender Increases Risk of Stroke and Readmission after CEA and CAS – Journal of Vascular Surgery (jvascsurg.org).

Rehabilitation focus

Nursing’s Role in Successful Stroke Care Transitions Across the Continuum: From Acute Care Into the Community.

Virtual reality in post-stroke neurorehabilitation – a systematic review and meta-analysis.

Outcomes of an interprofessional intensive comprehensive aphasia program’s first five years: Topics in Stroke Rehabilitation.

Use of the Leap Motion Controller® System in the Rehabilitation of the Upper Limb in Stroke.

WSO Position statement on Stroke care during COVID-19 pandemic | World Stroke Organization (world-stroke.org)

Source: World Stroke Organisation

Follow link for full article: WSO Position statement on Stroke care during COVID-19 pandemic | World Stroke Organization (world-stroke.org)

Date of publication: November 2021

In a nutshell: The World Stroke Organisation has issued a joint position statement with American Stroke and Heart Association on maintaining stroke care services during pandemic in low and middle income countries which have fragmented health care system and often face challenges in the delivery of stroke systems of care.

Length of publication: Position statement 

Primary stroke prevention worldwide: translating evidence into action

Source: The Lancet Public Health

Follow link for full article: Primary stroke prevention worldwide: translating evidence into action – The Lancet Public Health

Date of publication: October 2021

In a nutshell: This paper provides an overview of the current situation regarding primary prevention services, estimates the cost of stroke and stroke prevention and identifies deficiencies in existing guidelines and gaps in primary prevention.

Length of publication:  Policy paper  

 

 

Linking the Paul Coverdell National Acute Stroke Program to commercial claims to establish a framework for real-world longitudinal stroke research

Source: The BMJ

Follow link for full article:  Linking the Paul Coverdell National Acute Stroke Program to commercial claims to establish a framework for real-world longitudinal stroke research (bmj.com)

Date of publication: October 2021

In a nutshell: The article examines work to establish a framework for longitudinal research on

patients hospitalised with stroke by linking information-rich, deidentified inpatient data from the Paul Coverdell National Acute Stroke Program (PCNASP) to commercial and Medicare Advantage longitudinal claims data.

Length of publication: Research article  

Source: Stroke

Follow link for full article: Cilostazol Versus Aspirin on White Matter Changes in Cerebral Small Vessel Disease: A Randomized Controlled Trial | Stroke (ahajournals.org)

Date of publication: November 2021

In a nutshell: This study aimed to compare the effects of cilostazol and aspirin on changes in white matter change volume in patients with cerebral small vessel disease.

Length of publication: Research article  

Higher Risk of Ischemic Stroke After an Intracerebral Hemorrhage Than in General Population: A Cohort Study From the United Kingdom

Source: Stroke

Follow link for full article: Higher Risk of Ischemic Stroke After an Intracerebral Hemorrhage Than in General Population: A Cohort Study From the United Kingdom | Stroke (ahajournals.org) 

Date of publication: November 2021

In a nutshell: Is there a higher risk of ischemic stroke after an intracerebral hemorrhage.

Length of publication: Letter  

Outcome Prediction Models for Endovascular Treatment of Ischemic Stroke: Systematic Review and External Validation

Source: Stroke

Follow link for full article: Outcome Prediction Models for Endovascular Treatment of Ischemic Stroke: Systematic Review and External Validation | Stroke (ahajournals.org) 

Date of publication: November 2021

In a nutshell: The aim of the study is to provide an overview of preintervention models for functional outcome after endovascular treatment.

Length of publication: Research article

Collateral Supply in Preclinical Cerebral Stroke Models

Source: Translational Stroke Research

Follow link for full article: https://link.springer.com/article/10.1007%2Fs12975-021-00969-3

Date of publication: November 2021

In a nutshell: In this review the authors describe and illustrate the cerebral collateral systems and their modifications following pre-Willis or post-Willis occlusion in rodents.

Length of publication: Research article

Sex differences in predictors for cognitive decline and dementia in people with stroke or transient ischemic attack in the PROGRESS trial

Source: International Journal of Stroke

Follow link for full article: https://journals.sagepub.com/doi/10.1177/17474930211059298

Date of publication: November 2021

In a nutshell: The study evaluates overall and sex-specific differences in treatment effects for cognitive decline/dementia, as well as associations with vascular and stroke-specific predictors.

Length of publication: Research article

Estimating nocturnal stroke onset times by magnetic resonance imaging in the WAKE-UP trial

Source: International Journal of Stroke

Follow link for full article: https://journals.sagepub.com/doi/pdf/10.1177/17474930211059608

Date of publication: November 2021

In a nutshell: The study aims to estimate symptom onset during night-sleep in patients from the WAKE-UP trial based on relative signal intensities from acute stroke lesions.

Length of publication: Research article

Comparison of the Safety, Efficacy, and Procedural Characteristics Associated with Proximal and Distal Radial Access for Diagnostic Cerebral Angiography

Source: Journal of Stroke and Cerebrovascular Diseases

Follow link for full article: https://pubmed.ncbi.nlm.nih.gov/34781204/

Date of publication: November 2021

In a nutshell: Consecutive diagnostic cerebral angiograms performed at a single institution were retrospectively reviewed.

Length of publication: Research article

Optimal Management of Asymptomatic Carotid Stenosis in 2021: The Jury is Still Out. An International, Multispecialty, Expert Review and Position Statement

Source: Journal of Stroke and Cerebrovascular Diseases

Follow link for full article: Optimal Management of Asymptomatic Carotid Stenosis in 2021: The Jury is Still Out. An International, Multispecialty, Expert Review and Position Statement – PubMed (nih.gov)

Date of publication: November 2021

In a nutshell: This current multispecialty position statement aims to reconcile the conflicting views on management of asymptomatic carotid stenosis.

Length of publication: Position statement 

 

Robust Thrombolytic and Anti-Inflammatory Action of a Constitutively Active ADAMTS13 Variant in Murine Stroke Models

Source: Blood

Follow link for full article: https://ashpublications.org/blood/article/doi/10.1182/blood.2021012787/477972/Robust-Thrombolytic-and-Anti-Inflammatory-Action

Date of publication: November 2021

In a nutshell: A drug developed by scientists at the University of Manchester is able to effectively break down blood clots in the brains of mice that are resistant to current drugs,

Length of publication: Research article

Considerations for the Implementation of a Telestroke Network: A Systematic Review

Considerations for the Implementation of a Telestroke Network: A Systematic Review – PubMed (nih.gov)

Source: Journal of Stroke and Cerebrovascular Diseases

Follow link for full article: Considerations for the Implementation of a Telestroke Network: A Systematic Review – PubMed (nih.gov)

Date of publication: October 2021

In a nutshell: Given the prolific expansion of telestroke services since 2010, we conducted a systematic review to determine factors associated with successful establishment, management, and sustainability of a contemporary telestroke services.

Length of publication: Research article

Major research network to investigate body clock and stroke — Nuffield Department of Clinical Neurosciences

Source: Nuffield Department of Clinical Neurosciences

Follow link for full article: Major research network to investigate body clock and stroke — Nuffield Department of Clinical Neurosciences (ox.ac.uk)

Date of publication: October 2021

In a nutshell: The University of Oxford is part of a new international research network to investigate the interactions between the biology of the body’s internal clock and the disordered physiological processes associated with stroke.

Length of publication: Press release

Female Gender Increases Risk of Stroke and Readmission after CEA and CAS – Journal of Vascular Surgery (jvascsurg.org)

Source: Journal of Vascular Surgery

Follow link for full article:  Female Gender Increases Risk of Stroke and Readmission after CEA and CAS – Journal of Vascular Surgery (jvascsurg.org)

Date of publication: November 2021

In a nutshell: The authors suggest that there are significant differences in gender-based postoperative outcomes in surgical management of cerebrovascular disease and recommend adequate representation of female patients in studies to better understand gender-based disparities in carotid intervention.

Length of publication: Research article

Rehabilitation focus

Nursing’s Role in Successful Stroke Care Transitions Across the Continuum: From Acute Care Into the Community

Source: Stroke

Follow link for full article: Nursing’s Role in Successful Stroke Care Transitions Across the Continuum: From Acute Care Into the Community | Stroke (ahajournals.org)

Date of publication: November 2021

In a nutshell: This article aims to provide evidence on the important nursing roles in stroke care and transition management across the care continuum. It discusses cross-setting issues in stroke care and provide recommendations to leverage nursing’s impact in optimizing outcomes for stroke survivors and their family unit.

Length of publication: Review article

 

 

Virtual reality in post-stroke neurorehabilitation – a systematic review and meta-analysis

Source: Topics in Stroke Rehabilitation

Follow link for full article: Virtual reality in post-stroke neurorehabilitation – a systematic review and meta-analysis – PubMed (nih.gov)

Date of publication: November 2021

In a nutshell: A systematic review of the literature using the following keywords to retrieve the data: stroke, virtual reality, motor deficits, neurorehabilitation, cognitive impairments, and sensory deficits.

Length of publication: Systematic review

Outcomes of an interprofessional intensive comprehensive aphasia program’s first five years: Topics in Stroke Rehabilitation

Source: Topics in Stroke Rehabilitation

Follow link for full article: Outcomes of an interprofessional intensive comprehensive aphasia program’s first five years: Topics in Stroke Rehabilitation: Vol 0, No 0 (tandfonline.com)

Date of publication: November 2021

In a nutshell: This retrospective study investigated outcomes of the ICAP program, a collaboration between an institute of health professions and a rehabilitation hospital consisting of a six week intensive treatment program for people with post-stroke aphasia designed to maximize recovery and return to activities. 

Length of publication: Review article

Use of the Leap Motion Controller® System in the Rehabilitation of the Upper Limb in Stroke

Source: Journal of Stroke and Cerebrovascular Diseases

Follow link for full article: https://www.strokejournal.org/article/S1052-3057(21)00579-6/fulltext

Date of publication: November 2021

In a nutshell: An evaluation of the effectiveness of a virtual reality system in the treatment of upper limb functionality in people with stroke.

Length of publication: Systematic review

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Stroke Horizon Scanning Bulletin Volume 13 Issue 5

Contents

Young Adults Rehabilitation Needs and Experiences following Stroke (YARNS): A review of digital accounts to inform the development of age-appropriate support and rehabilitation.

Upper Limb Performance in Daily Life Approaches Plateau Around Three to Six Weeks Post-stroke.

Screening for aspiration risk associated with dysphagia in acute stroke.

Depression after stroke.

A First in Stroke Rehabilitation.

Changing the conversation from ‘chronic disease’ to ‘chronic health’

Blood Pressure in the First 6 Hours Following Endovascular Treatment for Ischemic Stroke Is Associated With Outcome.

European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment.

Representation of Women in Stroke Clinical Trials: A Review of 281 Trials Involving More Than 500,000 Participants.

The Association of Socioeconomic Status and Discharge Destination with 30-Day Readmission after Ischemic Stroke.

Clinical Performance Measures for Stroke Rehabilitation: Performance Measures From the American Heart Association/American Stroke Association.

Thrombolysis in Mild Stroke.

Antioxidant drug reverses process responsible for heart attacks and strokes.

Lack of knowledge on acute stroke in children, adolescents and adults from public schools.

What heart and stroke patients should know about COVID-19 vaccine boosters.

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Stroke Horizon Scanning Bulletin Volume 13 Issue 4

 

 

 

Please find the September 2021 issue of the Stroke Horizon Scanning Bulletin below.

Contents include

Factors influencing the use of different methods of consent in a randomized acute stroke trial: The Third International Stroke Trial (IST-3)

Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine

Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study

SaeboGlove therapy for upper limb disability and severe hand impairment after stroke (SUSHI): Study protocol for a randomised controlled trial

European stroke organization interim expert opinion on cerebral venous thrombosis occurring after SARS-CoV-2 vaccination.

Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization

Intracranial aneurysm wall enhancement as an indicator of instability – Systematic Review and Meta-Analysis 

Distinct intraarterial Clot Localizations affect Tissue-Level Collaterals and Venous Outflow Profiles

Serum Zinc Levels and Incidence of Ischemic Stroke: The Reasons for Geographic and Racial Differences in Stroke Study

Association Between Excess Leisure Sedentary Time and Risk of Stroke in Young Individuals

Clinical Performance Measures for Stroke Rehabilitation: Performance Measures From the American Heart Association/American Stroke Association

Mobile Interventional Stroke Teams Improve Outcomes in the Early Time Window for Large Vessel Occlusion Stroke  

Changes in Stroke Hospital Care During the Covid-19 Pandemic: A Systematic Review and Meta-Analysis 

Incidence and Outcomes of Hemorrhagic Stroke among Adults in Spain (2016–2018) According to Sex: A Retrospective, Cohort, Observational, Propensity Score Matched Study

Clinical Evaluation of Different Treatment Strategies for Motor Recovery in Poststroke Rehabilitation during the First 90 Days

Acute Reperfusion Therapies for Acute Ischemic Stroke

Factors influencing the use of different methods of consent in a randomized acute stroke trial: The Third International Stroke Trial (IST-3)

Source: International Journal of Stroke

Follow link for full article

Date of publication: August 2021

In a nutshell: Obtaining informed consent in people with acute stroke is complex since many, as a direct result of their stroke, lose capacity to make important decisions. Furthermore, reperfusion interventions are time dependent necessitating rapid consent. We developed four different consent approaches to facilitate recruitment of a broad range of patients in the Third International Stroke Trial (IST-3).

Length of publication: Research article

Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine

Source: International Journal of Stroke

Follow link for full article

Date of publication: August 2021

In a nutshell: Frailty is a distinctive health state in which the ability of older people to cope with acute stressors is compromised by an increased vulnerability brought by age-associated declines in physiological reserve and function across multiple organ systems. Although closely associated with age, multimorbidity, and disability, frailty is a discrete syndrome that is associated with poorer outcomes across a range of medical conditions. However, its role in cerebrovascular disease and stroke has received limited attention. The estimated rise in the prevalence of frailty associated with changing demographics over the coming decades makes it an important issue for stroke practitioners, cerebrovascular research, clinical service provision, and stroke survivors alike. This review will consider the concept and models of frailty, how frailty is common in cerebrovascular disease, the impact of frailty on stroke risk factors, acute treatments, and rehabilitation, and considerations for future applications in both cerebrovascular clinical and research settings.

Length of publication: Research article

Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study

Source: The Lancet

Follow link for full article

Date of publication: July 2021

In a nutshell: Covid-19 is a complex disease targeting many organs. Previous studies highlight Covid-19 as a probable risk factor for acute cardiovascular complications. This study aims to quantify the risk of acute myocardial infarction and ischaemic stroke associated with COVID-19 by analysing all Covid-19 cases in Sweden.

Length of publication: Research article

SaeboGlove therapy for upper limb disability and severe hand impairment after stroke (SUSHI): Study protocol for a randomised controlled trial

Source: European Stroke Journal

Follow link for full article

Date of publication: August 2021

In a nutshell: Impaired active digital extension is common after stroke, hindering functional rehabilitation, and predicting poor recovery. The SaeboGlove assists digital extension and may improve outcome after stroke. We recently performed a single group, open, pilot trial of the SaeboGlove early after stroke which demonstrated satisfactory safety, feasibility and acceptability. An adequately powered randomised clinical trial is now needed to assess the clinical effectiveness of the SaeboGlove.

Length of publication: Research article

European stroke organization interim expert opinion on cerebral venous thrombosis occurring after SARS-CoV-2 vaccination

Source: European Stroke Journal

Follow link for full article

Date of publication: July 2021

In a nutshell: Severe cases of cerebral venous thrombosis with thrombocytopenia and anti-platelet factor 4 antibodies occurring after adenoviral vector anti-SARS-CoV-2 vaccines have recently been reported. This study aims to present a guidance document on the diagnosis and treatment of patients presenting with CVT after vaccination against SARS-CoV-2 infection.

Length of publication: Research article

Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization

Source: European Stroke Journal

Follow link for full article

Date of publication: July 2021

In a nutshell: This article assesses the correlation between thrombus size before and after mechanical thrombectomy, measured as length by computed tomography angiography/non-contrast computed tomography and extracted clot area respectively. It also assesses the influence of thrombus size on the number of passes required for clot removal and final recanalization outcome.

Length of publication: Research article

Intracranial aneurysm wall enhancement as an indicator of instability – Systematic Review and Meta-Analysis

Source: European Journal of Neurology

Follow link for full article

Date of publication: August 2021

In a nutshell: Aneurysm wall enhancement of intracranial aneurysms on MRI has been described as a surrogate marker of instability by previous studies. In this study, an updated literature overview and summary risk estimates of the association between AWE and different specific outcomes (i.e. rupture, growth, or symptomatic presentation) for both cross-sectional and longitudinal studies.

Length of publication: Systematic review

Distinct intraarterial Clot Localizations affect Tissue-Level Collaterals and Venous Outflow Profiles

Source: European Journal of Neurology

Follow link for full article

Date of publication: August 2021

In a nutshell: Arterial clot localization affects collateral flow to ischemic brain in patients with acute ischemic stroke due to large vessel occlusion. This study determined the association between vessel occlusion locations, tissue-level collaterals and venous outflow profiles and their impact on good functional outcomes.

Length of publication: Research article

Serum Zinc Levels and Incidence of Ischemic Stroke: The Reasons for Geographic and Racial Differences in Stroke Study

Source: Stroke

Follow link for full article

Date of publication: August 2021

In a nutshell: Despite zinc’s role as an antioxidant and anti-inflammatory agent, prospective studies relating zinc levels to ischemic stroke risk are lacking. This article aims to examine the association between serum zinc levels and incidence of ischemic stroke in a US population.

Length of publication: Research article

Association Between Excess Leisure Sedentary Time and Risk of Stroke in Young Individuals

Source: Stroke

Follow link for full article

Date of publication: August 2021

In a nutshell: The association between physical activity and lower risk of stroke is well established, but the relationship between leisure sedentary time and stroke is less well studied.

Length of publication: Research article

Clinical Performance Measures for Stroke Rehabilitation: Performance Measures From the American Heart Association/American Stroke Association

Source: Stroke

Follow link for full article

Date of publication: August 2021

In a nutshell: The American Heart Association/American Stroke Association released the adult stroke rehabilitation and recovery guidelines in 2016. A working group of stroke rehabilitation experts reviewed these guidelines and identified a subset of recommendations that were deemed suitable for creating performance measures. These 13 performance measures are reported here and contain inclusion and exclusion criteria to allow calculation of rates of compliance in a variety of settings ranging from acute hospital care to post acute care and care in the home and outpatient setting.

Length of publication: Review article

Mobile Interventional Stroke Teams Improve Outcomes in the Early Time Window for Large Vessel Occlusion Stroke

Source: Stroke

Follow link for full article

Date of publication: August 2021

In a nutshell: Endovascular thrombectomy for large vessel occlusion stroke is a time-sensitive intervention. The use of a Mobile Interventional Stroke Team traveling to Thrombectomy Capable Stroke Centers to perform endovascular thrombectomy has been shown to be significantly faster with improved discharge outcomes, as compared with the drip-and-ship model.

Length of publication: Brief

Changes in Stroke Hospital Care During the Covid-19 Pandemic: A Systematic Review and Meta-Analysis

Source: Stroke

Follow link for full article

Date of publication: August 2021

In a nutshell: The present systematic review and meta-analysis indicates an increased prevalence of younger patients, more severe strokes attributed to large vessel occlusion, and higher endovascular treatment rates during the Covid-19 pandemic. Patients admitted with stroke during the Covid-19 pandemic had higher in-hospital mortality. These findings need to be interpreted with caution in view of discrepant reports and heterogeneity being present across studies.

Length of publication: Systematic Review

Incidence and Outcomes of Hemorrhagic Stroke among Adults in Spain (2016–2018) According to Sex: A Retrospective, Cohort, Observational, Propensity Score Matched Study

Source: Journal of Clinical Medicine

Follow link for full article

Date of publication: August 2021

In a nutshell: This article aims to analyse sex differences in the incidence, clinical characteristics and in-hospital outcomes of hemorrhagic stroke (HS) in Spain (2016–2018) using the National Hospital Discharge Database. Increments in age, comorbidity and use of anticoagulants and antiplatelet agents prior to hospitalization were associated were higher IHM, and decompressive craniectomy was associated with lower IHM in both sexes. Men had higher incidence rates of HS than women. Women less often underwent decompressive craniectomy. IHM was higher among women admitted for HS than among men.

Length of publication: Research article

Clinical Evaluation of Different Treatment Strategies for Motor Recovery in Poststroke Rehabilitation during the First 90 Days

Source: Journal of Clinical Medicine

Follow link for full article

Date of publication: August 2021

In a nutshell: Motor recovery after stroke is based on neuronal plasticity and the structural reorganization of the brain. Questions are debated about the proper moment to start rehabilitation in the acute period of stroke, the significance of rehabilitation interventions during the so-called “plastic window”, and the advantages of modern and traditional programs. The aims of this study were to evaluate the role of different rehabilitation strategies and their combinations for motor recovery and the impact on functional disability by way of neurological and functional outcomes three months after ischemic stroke.

Length of publication: Research article

Acute Reperfusion Therapies for Acute Ischemic Stroke

Source: Journal of Clinical Medicine

Follow link for full article

Date of publication: August 2021

In a nutshell: The field of acute stroke treatment has made tremendous progress in reducing the overall burden of disability. Understanding the pathophysiology of acute ischemic injury, neuroimaging to quantify the extent of penumbra and infarction, and acute stroke reperfusion therapies have together contributed to these advancements.

Length of publication: Research article

Stroke Horizon Scanning Bulletin Volume 13 Issue 3

Please find the July 2021 issue of the Stroke Horizon Scanning Bulletin below.

Contents include:

New risk calculator to help save many more lives from heart attack and stroke

Drugs to stabilise plaques could prevent stroke.

Clinical Effectiveness of the Queen Square Intensive Comprehensive Aphasia Service for Patients With Poststroke Aphasia 

An update on hyper-acute management of ischaemic stroke.

Lower risk of stroke after alcohol abstinence in patients with incident atrial fibrillation: a nationwide population-based cohort study

Anemia a Risk Factor for the Development of Ischemic Stroke and Post-Stroke Mortality

Effect of Possible Osteoporosis on Parenchymal-Type Hemorrhagic Transformation in Patients with Cardioembolic Stroke

Effect of COPD on the Hospital Outcomes and Mortality among Hemorrhagic Stroke Patients. Sex Differences in a Population-Based Study

Task-Oriented Circuit Training as an Alternative to Ergometer-Type Aerobic Exercise Training after Stroke

Influence of the Passive Stabilization of the Trunk and Upper Limb on Selected Parameters of the Hand Motor Coordination, Grip Strength and Muscle Tension, in Post-Stroke Patients

Effect of Posterior Pelvic Tilt Taping on Pelvic Inclination, Muscle Strength, and Gait Ability in Stroke Patients: A Randomized Controlled Study

Going the Extra Mile: Disparities in Access to Specialized Stroke Care

Demographic Disparities in Proximity to Certified Stroke Care in the United States

A randomized prospective multi-center trial for stroke prevention by prophylactic surgical closure of the left atrial appendage in patients undergoing bioprosthetic aortic valve surgery––LAA-CLOSURE trial protocol

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Stroke Horizon Scanning Bulletin Volume 13 Issue 2

Please find the March 2021 issue of the Stroke Horizon Scanning Bulletin below.

Contents include:

New national study into neurological impact of COVID-19.

Lowering blood pressure is even more beneficial than previously thought.

New genetic clues point to new treatments for ‘silent’ stroke.

3D heart scans on the NHS to speed up disease diagnosis.

COVID-19 and stroke—Understanding the relationship and adapting services. A global World Stroke Organisation perspective.

Efficacy of Brain–Computer Interface and the Impact of Its Design Characteristics on Poststroke Upper-limb Rehabilitation: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Guided versus standard antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.

Location of infarcts and post-stroke cognitive impairment.

Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.

Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial

Stroke 20 20: Implementation goals for intravenous thrombolysis.

Effects of Combined Interventions with Aerobic Physical Exercise and Cognitive Training on Cognitive Function in Stroke Patients: A Systematic Review.

Association between abnormal body weight and stroke outcome: A meta-analysis and systematic review

Scoping review: Health needs of the family caregivers of elderly stroke survivors.

Effectiveness of information and communications technology interventions for stroke survivors and their support people: a systematic review.

Antihypertensive Drugs for Secondary Prevention After Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis.

Stroke Bulletin May 2021Download

Stroke Horizon Scanning Bulletin Volume 13 Issue 1

Please find the March 2021 issue of the Stroke Horizon Scanning Bulletin below.

Contents include:

Stroke Association and BASP write open letter to GPs after vaccine rollout concerns raised. 2

Zinc could be key to new diabetes treatments. 3

Government action needed to avoid 12,000 extra heart attacks and strokes. 4

Relaunch of the Act FAST campaign to improve stroke outcomes. 4

Swallowing, Oral Motor, Motor Speech, and Language Impairments Following Acute Pediatric Ischemic Stroke. 4

Spontaneous Cervical Artery Dissection in Vascular Ehlers-Danlos Syndrome. 6

Outcomes of Large Vessel Occlusion Stroke in Patients Aged ≥90 Years. 7

Epidemiological Surveillance of the Impact of the COVID-19 Pandemic on Stroke Care Using Artificial Intelligence. 8

Temporal Trends in Stroke-Related Memory Change. 9

Higher-Quality Data Collection Is Critical to Establish the Safety and Efficacy of Pediatric Mechanical Thrombectomy. 11

Impact of Delirium and Its Motor Subtypes on Stroke Outcomes. 12

Predictors of Poststroke Aphasia Recovery. 13

Predictors of Daily Steps at 1-Year Poststroke. 14

Association Between Stroke and Subsequent Risk of Suicide. 15

Predictors of Daily Steps at 1-Year Poststroke. 16

Intraluminal Thrombus and Outcomes of Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Treatment 17

Diagnosis and Management of Transient Ischemic Attack and Acute Ischemic Stroke. 18

A meta-analysis of aspirin and subarachnoid haemorrhage in patients with intracranial aneurysms yields different results to the general population. 20

Stroke risk following traumatic brain injury: systematic review and meta-analysis. 21

European Stroke Organisation expedited recommendation for the use of short-term dual antiplatelet therapy early after minor stroke and high-risk TIA.. 22

European Stroke Organisation (ESO) guidelines on management of transient ischaemic attack. 22

The use of hypnotherapy as treatment for functional stroke: A case series from a single center in the UK   23

Stroke March 2021Download

Stroke Horizon Scanning Bulletin Volume 12 Issue 8

Happy New Year to all our readers. We are thinking of you all and hope you are keeping safe.

Please find the December 2020 issue of the Stroke Horizon Scanning Bulletin below.

Contents include:

• Stroke Prevention in Atrial Fibrillation: Looking Forward
• ReStore Soft Exo-Suit for gait rehabilitation: Medtech innovation briefing [MIB239]
• COVID-19 associated arterial ischaemic stroke and multisystem inflammatory syndrome in children: a case report
• Age in relation to comorbidity and outcome in patients with high-risk TIA or minor ischemic stroke: A Swedish national observational study
• Safety and Outcome of Decompressive Hemicraniectomy After Recombinant Tissue Plasminogen Activator Thrombolysis for Acute Ischemic Stroke: A Systematic Review
• Venous and arterial thromboembolic events with immune checkpoint inhibitors: A systematic review
• Prevalence of atrial fibrillation and outcomes in older long-term care residents: a systematic review.
• Multivariable risk scores for predicting short term outcomes for emergency department patients with unexplained syncope: a systematic review
• Long-Term Efficacy of Extracorporeal Shock Wave Therapy on Lower Limb Post-Stroke Spasticity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
• Interventions for improving oral health in people after stroke
• Fluoxetine for stroke recovery improvement – the doubleblind, randomised placebo-controlled FOCUS-Poland trial
• Five-Year Risk of Acute Myocardial Infarction After Acute Ischemic Stroke in Korea.
• Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials
• Heterogeneity of diabetes as a risk factor for major adverse cardiovascular events in anticoagulated patients with atrial fibrillation: an analysis of the ARISTOTLE trial 19
• Iron chelators for acute stroke
• Blood pressure targets in adults with hypertension
• Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride
• Does coronavirus cause stroke? A look at the current research
• Stroke risk, phenotypes, and death in COVID-19: Systematic review and newly reported cases
• Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis
• Patterns of Infarction on MRI in Patients With Acute Ischemic Stroke and Cardio-Embolism: A Systematic Review and Meta-Analysis
• Antiphospholipid Antibody and Recurrent Ischemic Stroke: A Systematic Review and Meta-Analysis
• Quality of Stroke Patient Information Applied in Randomized Controlled Trials-Literature Review
• A systematic review of social service and community resource interventions following stroke
• The Association of Overt and Subclinical Hyperthyroidism with the Risk of Cardiovascular Events and Cardiovascular Mortality: Meta-Analysis and Systematic Review of Cohort Studies
• Scientists test new “algorithm” to help prevent heart attacks
• Symptoms of depression linked to increased risk of heart disease and stroke
• People with heart and circulatory conditions at higher risk of dying from flu
• Trial resumes to prevent dementia after a stroke
• Scientists discover why the heart slows down at night
• The BHF’s research highlights of 2020
• THROMBOLYSIS IN UNKNOWN STROKE ONSET: BROADENING THE HORIZON WITH ADVANCED BRAIN IMAGING

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Stroke Horizon Scanning Bulletin Volume 12 Issue 7

Stroke Prevention in Older Adults

Source: Stroke

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Date of publication: 30 October 2020

Publication type: Research Article

In a nutshell:

The risks of stroke and dementia increase steeply with age, and both are preventable. At present, the best way to preserve cognitive function is to prevent stroke. Therapeutic nihilism based on age is common and unwarranted. We address recent advances in stroke prevention that could contribute greatly to prevention of stroke and dementia at a time when the aging of the population threatens to markedly increase the incidence of both. Issues discussed: (1) old patients benefit even more from lipid-lowering therapy than do younger patients; (2) patients with stiff arteries are at risk from a target systolic blood pressure <120 mm Hg; (3) the interaction of the intestinal microbiome, age, and renal function has important dietary implications for older adults; (4) anticoagulation with direct-acting oral anticoagulants should be prescribed more to old patients with atrial fibrillation; (5) B vitamins to lower homocysteine prevent stroke; and (6) most old patients in whom intervention is warranted for carotid stenosis would benefit more from endarterectomy than from stenting. An 80-year-old person has much to lose from a stroke and should not have effective therapy withheld on account of age. Lipid-lowering therapy, a more plant-based diet, appropriate anticoagulation or antiplatelet therapy, appropriate blood pressure control, B vitamins to lower homocysteine, and judicious intervention for carotid stenosis could do much to reduce the growing burden of stroke and dementia.

Length of publication: Journal article

Some important notes:  Please contact your local NHS library for the full text of this article. Follow this link to find your local NHS library.

Cost of stroke care will soar in coming years without investment in prevention

Source: GM

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Date of publication: 16 October 2020

Publication type: Web Article

Details

As it launches its Winter Resilience Campaign, Age UK publishes new research that shows just how crushingly hard day to day life has been for millions of older people during the pandemic and how important it is that we support our older population through the winter.

Length of publication: Web article

Simulation training programs for acute stroke care: Objectives and standards of methodology

Source: European Stroke Journal

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Date of publication: 1^st November 2020

Publication type: Research Article

In a nutshell:

The European Stroke Organisation (ESO) Simulation Committee was established in 2017 with the intent to promote simulation education and training in the stroke field. The application of simulation methodology in education and training improves healthcare professional performances in real clinical practice and patient outcomes. We evaluated the implementation of simulation training in stroke medicine, how it can significantly affect stroke pathways and quality of care. We herewith describe simulation techniques in the acute stroke setting. Simulation programs place the trainees in a safe environment, allowing both role-playings for decision making training and procedural simulation for technical skills improvement. This paper includes the position of the Committee on the key points, principles, and steps in order to set up and promote simulation programs in European stroke centers. Stroke is an emergency, and hyperacute phase management requires knowledge, expertise, optimal multidisciplinary team working, and timely actions in a very narrow time window. The ESO Simulation Committee promotes the implementation of simulation training in stroke care according to a specific and validated methodology.

Length of publication: Journal article

Some important notes:  Please contact your local NHS library for the full text of this article. Follow this link to find your local NHS library.

Robot-assisted training compared with an enhanced upper limb therapy programme and with usual care for upper limb functional limitation after stroke: the RATULS three-group RCT

Source: Health Technology Assessment

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Date of publication: 21^st October 2020

Publication type: Research Article

In a nutshell:

Abstract

Objective: The objectives were to determine the clinical effectiveness and cost-effectiveness of robot-assisted training, compared with an enhanced upper limb therapy programme and with usual care.

Design: This was a pragmatic, observer-blind, multicentre randomised controlled trial with embedded health economic and process evaluations.

Interventions: Robot-assisted training using the Massachusetts Institute of Technology-Manus robotic gym system (InMotion commercial version, Interactive Motion Technologies, Inc., Watertown, MA, USA), an enhanced upper limb therapy programme comprising repetitive functional task practice, and usual care.

Main outcome measures: The primary outcome was upper limb functional recovery ‘success’ (assessed using the Action Research Arm Test) at 3 months. Secondary outcomes at 3 and 6 months were the Action Research Arm Test results, upper limb impairment (measured using the Fugl-Meyer Assessment), activities of daily living (measured using the Barthel Activities of Daily Living Index), quality of life (measured using the Stroke Impact Scale), resource use costs and quality-adjusted life-years.

Results: A total of 770 participants were randomised (robot-assisted training, n = 257; enhanced upper limb therapy, n = 259; usual care, n = 254). Upper limb functional recovery ‘success’ was achieved in the robot-assisted training [103/232 (44%)], enhanced upper limb therapy [118/234 (50%)] and usual care groups [85/203 (42%)]. These differences were not statistically significant; the adjusted odds ratios were as follows: robot-assisted training versus usual care, 1.2 (98.33% confidence interval 0.7 to 2.0); enhanced upper limb therapy versus usual care, 1.5 (98.33% confidence interval 0.9 to 2.5); and robot-assisted training versus enhanced upper limb therapy, 0.8 (98.33% confidence interval 0.5 to 1.3). The robot-assisted training group had less upper limb impairment (as measured by the Fugl-Meyer Assessment motor subscale) than the usual care group at 3 and 6 months. The enhanced upper limb therapy group had less upper limb impairment (as measured by the Fugl-Meyer Assessment motor subscale), better mobility (as measured by the Stroke Impact Scale mobility domain) and better performance in activities of daily living (as measured by the Stroke Impact Scale activities of daily living domain) than the usual care group, at 3 months. The robot-assisted training group performed less well in activities of daily living (as measured by the Stroke Impact Scale activities of daily living domain) than the enhanced upper limb therapy group at 3 months. No other differences were clinically important and statistically significant. Participants found the robot-assisted training and the enhanced upper limb therapy group programmes acceptable. Neither intervention, as provided in this trial, was cost-effective at current National Institute for Health and Care Excellence willingness-to-pay thresholds for a quality-adjusted life-year.

Conclusions: Robot-assisted training did not improve upper limb function compared with usual care. Although robot-assisted training improved upper limb impairment, this did not translate into improvements in other outcomes. Enhanced upper limb therapy resulted in potentially important improvements on upper limb impairment, in performance of activities of daily living, and in mobility. Neither intervention was cost-effective.

Length of publication: Journal article

Some important notes:  Please contact your local NHS library for the full text of this article. Follow this link to find your local NHS library.